ࡱ> i RzbjbjڲڲF؏\؏\ui1 ;;d/@; """#), -:::::::>@N:iE.))E.E.:;;"# :111E.;";"L:1E.:11+5|@5"-E.5{:;0@;5AE.pA$5A5E.E.1E.E.E.E.E.::1E.E.E.@;E.E.E.E.AE.E.E.E.E.E.E.E.E. I : DN SYT[hQċ0Ob/g[R 2021t^Hr v U_  TOC \o "1-1" \h \z \u  HYPERLINK \l "_Toc67575716" 1.(uV 5  HYPERLINK \l "_Toc67575717" 2.W,gSRNBl 5  HYPERLINK \l "_Toc67575718" 3.SYT[hQċ0ONXTvBl 6  HYPERLINK \l "_Toc67575719" 4.Θiċ0O z^ 6  HYPERLINK \l "_Toc67575720" 5.ktf[xvz 13  HYPERLINK \l "_Toc67575721" 6.Sev[hQċ0O  PAGEREF _Toc67575721 \h 17  HYPERLINK \l "_Toc67575722" 7.SYTNTv[hQċ0O 23  HYPERLINK \l "_Toc67575723" 8.[hQċ0ObJT 26  HYPERLINK \l "_Toc67575724" 9.f  PAGEREF _Toc67575724 \h 27  HYPERLINK \l "_Toc67575725" 10./g틌TʑIN 29  HYPERLINK \l "_Toc67575726" DU_1SYTSev[hQċ0ObJT  PAGEREF _Toc67575726 \h 33  HYPERLINK \l "_Toc67575727" DU_2SYTNTv[hQċ0ObJT  PAGEREF _Toc67575727 \h 38  HYPERLINK \l "_Toc67575728" DU_3SYT[hQċ0ObJT:yO[teHr 43  HYPERLINK \l "_Toc67575729" DU_4SYT[hQċ0ObJT:yO{SHr  PAGEREF _Toc67575729 \h 55  SYT[hQċ0Ob/g[R :NOSYTO(u[hQ ĉSYT[hQċ0O c[_U\vsQ]\O 6R[,g[R0 (uV ,g[R(uNSYTSeTNTv[hQċ0O0 W,gSRNBl 2.1 Sev[hQ'`/fSYTNT[hQvMRcagN0SYTSevΘiċ0OSbSe,gSS&^eQvΘiir(SYTNTN,S:N/fTySev~T ^WN@b gSeTΘiir(ۏLċ0O YgnxgNSeKNX[(WSf[T/buirf[I{vN\O(uv ^ċ0OvQNuvΘiir(T/bvN\O(uNuv\o(W[hQΘi0 2.2 SYT[hQċ0O^u_ncCg͑SR Ns gyf[pencTvsQOo`:NW@x u_yf[0lQck0fT*NHhRgvSR (W[eǏ z-N^O[hQċ0O]\Ovrz'`0 2.3 SYT[hQċ0O_(uvSDe^:NhQeb__lQ_Shvb/gbJT0JT0NNfNM|bf[/ge NSVECgZ:ggS^vpencbΘiċ0ODeI{^(u*glQ_Shvxvz~ge ~penc@b gCge Ta v^Rg~gvyf['`0Qnx'`0w['`TS`'`I{0 2.4 SYTv[hQċ0O]\O^1uwQ gv^Rv[hQċ0ONXT cgq,g[RvBlۏLċ0O v^QwQċ0ObJT0 2.5 SYTlQN0YHhN^LbYXbNN:gg_U\[hQċ0O b_b[hQċ0ObJT v^[vQw['`0yf['`#0 2.6 SYTv[hQċ0ODe^S_9hncSefe OX[gP N\NgTNyb N^NTO(g~_gNT10t^0 2.7 SYT[hQċ0ONXT_U\[hQċ0Oe N,g[R\O:NSOnc ؏^9hncSeTNTvwQSO`QۏLRg0 2.8 ċ0ONXTv{S^D(Wċ0ObJTKNT {SQ[^Sbċ0ONXTvYe~S0SYTvsQNN~S0NNW~SI{0 3. SYT[hQċ0ONXTvBl SYT[hQċ0ONXT^&{TN NBl 3.1 wQ g;Sf[0of[0uirf[0Sf[bktf[I{SYT(ϑ[hQvsQNNwƋ NSYTbTbSeuNǏ zT(ϑ[hQc6RBl v^wQ g5t^N NvsQNNNN~S0 3.2 gTRgSf[0ktf[I{vsQe.sOo` Rg0ċ0OTʑvsQpenc0 3.3 lQs^0[‰0WRgSYTv[hQ'` (WhQbRg@b gS_vpencTf2agNvW@x N _U\[hQċ0O]\O,v^[ċ0ObJTvyf['`0Qnx'`0w['`TS`'`#0 3.4 Ǐ[gcSv^vNNWI{e_ f[`N[hQċ0OvvsQwƋ N㉌Tccev[hQċ0Ot0b/gTel v^(uN[0 4. Θiċ0O z^ SYTSeTΘiir(vΘiċ0O z^R:NN NV*Nek 4.1 qS[Ƌ+R WNktf[Ջ04N^xvz0 NoS^vKmTNAmLuf[xvzI{v~g NSeT/bΘiir(virt0Sf[Tk\O(uyr_egnx[vQ/f&T[NSOeP^X[(W\o(WqS[0 4.1.1 eP^qS[He^ 9hncNTvO(uel0f2_I{ nxSeT/bΘiir(SX[(WveP^qS[He^ ;NSb 1 %`'`k'`Sb~ST/b~vcTNuv%`'`k'`He^0 2 :Ro'`/P'`SbvT/b1202 qp>200! 8T6esN10%Sf[Tbv1uNybNyN N~gUSCQ ǏqQN.c s^GWv[RP[(ϑ'YN1000S\ Nv[RP[(ϑ\N1000S\vNOZSO+Tϑ\N10% ~gT'`(3z[vZTirwQ gؚuir;m'`vSedY S NQv8T6e08T6es NN100%e cO gsQ`Qf0 5.12 vQNktf[ՋDe g~|T8TS8T6eSe cO8TeQk'`ՋDe_eScOvQN gRNhfSeT/bΘiir(k'`vktf[ՋDe0 5.13 N[hQ'`ՋDe SbNSO[hQ'`ՋDeTNAmLuf[De0 NAmLuf[DeSbNAmLuf[g0NvKmNS4N^ NoNNbJT0NEebJTI{0 Sev[hQċ0O 6.1 [hQċ0OSR 6.1.1 cgqΘiċ0O z^[SYTSeT/bvQSX[(WvΘiir(ۏLċ0O OSeO(uv[hQ'`0 6.1.2 O(u 0b/gĉ 0-NvP(u~R0Q(u2PBR0Q(u2RfBR0Q(u@wrBRTQ(ugSBRRh-NvSe^n 0b/gĉ 0Bl0 6.1.3 QVECgZSYT[hQċ0O:gg]lQ^ċ0O~vSe [vsQċ0ODeۏLRg (W&{TbVSYTvsQlĉBlv`Q N SǑ(uvsQċ0O~0 N TvCgZ:ggċ0O~g NNe 9hncpencvS`'`TvsQ'` yf[Tt0WǑ(uvsQċ0O~0 6.1.4 QNLukSu~~WHO 0TTV|Q~~FAO I{CgZ:gg]lQ^v[hQPϑb~ YkeAQDdeQϑADI 0keSBRϑTDI 0SBRϑRfD 0N,:N[hQir(GRAS 0wQ g`ENߘ(uSSvSeI{ [vsQDeۏLRg (W&{TbVSYTvsQlĉĉ[v`Q N SǑ(uvsQ~0Y:\@\k'`De [vQ@\k'`SL_U\ċ0O0 N TvCgZ:ggċ0O~g NNe 9hncpencvS`'`TvsQ'` yf[Tt0WǑ(uvsQċ0O~0 6.1.5 Y|&{TbVvsQV[hQbVEe(ueOSOIFRA hQ [vsQċ0ODeۏLRg (W&{TbVSYTvsQlĉBlv`Q N SǑ(uvsQċ0O~0 6.1.6 [NSf[~gfnx N NS+T%N͑zSfJT~gvSebΘiir( +TϑNON:ON|~ktf[xvzpence SSO(uktf[sQle\'`Sf[ir(TSf[~g*gwvmTirI{0 6.1.7 [N:ON|~ktf[xvzpencv^RHebRbΘiir( SSO(uR~/NSSgqGrouping/Read Across ۏLċ0O0@bSgqvSf[irN募SebΘiir( gvfWf2egne YvQNSYT0ߘT0sXI{ (W{[hQE20SOy 0ؚ/NOpHfXRR bck8^O(uNT[%N͑ NoS^v; 4 vQNq_TNT(ϑ[hQv`Q0 7.5 ?QzSYTċ0OBl 7.5.1 ۏL?QzSYTċ0Oe (WqS[Ƌ+R0f2ϑ{I{eb ^~T?Qzutyrp0 7.5.2 ^fnxvQMevSR v^[MeO(uSev_'`ۏLf yr+R/fe0@wrBR02PBRShb;m'`BRI{Se0 7.5.3 SR N NAQO(uN[ye}v0[yu01k0d0SQ\021S0gS0pS:NvvvSe YVvQNvvO(uSwQ g NRHevSee [O(uv_'`S[?QzSYTO(uv[hQ'`ۏLċN0 7.5.4 ^ (u gg[hQO(uSSvSYTSe NRO(uWVb/g0~s|b/gI{eb/g6RYvSe YefNSe_{O(ue fSV v^[?QzSYTO(uv[hQ'`ۏLċN0 8. [hQċ0ObJT 8.1 SYTSev[hQċ0ObJT SYTSev[hQċ0ObJT8^SbXd0SetS'`(0ċ0OǏ z0ċ0O~gRg0Θic6Rceb^0[hQċ0O~0[hQċ0ONXT~{ TS{S0Se.sTDU_I{Q[0 Sk:NSYT[hQċ0O-N@bmSvhQ萅Q[ [EۏLNTċ0Oe ċ0ONXT cgq,g[R~TNTvwQSO`QۏLċ0O0 /g틌TʑIN NR/g틌TʑIN(uN,g[R0 10.1 qSHazard SebΘiir((Wf2`Q N[NSONu NoHe^v^\'`0 10.2 ΘiRisk f2agN N SebΘiir([O(uNu g[\O(uvS'`S:_^v[ϑb['`0O0 10.3 Θiir(Risk Substance SYT-NSX[(Wv[hQ'`Θiir(/fc1uSYTSe&^eQ0uNǏ z-NNub&^eQv S[NSOeP^ bqS[vir(0 10.4 BRϑDose vcN:gSOv8T6eMOmSS0|0vI{ c SO8T6evϑ 8^Nmg/kgbwh:y0 10.5 *g‰[0R g[\O(uvBRϑNo Observed Adverse Effect Level NOAEL (Wĉ[vՋagN N (us gvb/gKbkbhKmch*g‰[0RNUONSՋir gsQvk'`\O(uvg'YBRϑ0 10.6 ‰[0R g[\O(uvgNOBRϑLowest Observed Adverse Effect Level LOAEL (Wĉ[vՋagN N SՋir_w[Rir~~b_`0R0uSI{ g[He^vgNOBRϑ0 10.7 WQBRϑBenchmark Dose BMD Nyir(_wgyyr[v0NOeP^ΘiSusN,(W1%^10%KN vBRϑ0 10.8 g@BDFJNPRǼv`vVJ:J0jhjzPJUhjz0J>*B*PJaJphjhjzPJUaJhjzaJmHsH*hjzB*CJ,OJPJQJ^JaJ,o(ph2hjzB*CJ,OJPJQJ^JaJ,mHo(phsH+hjzB*CJ$OJQJ^JaJ$mHphsH+hjzB*CJ OJQJ^JaJ mHphsHhjz5CJ PJaJ hjzCJ$PJaJ$hjzCJ4PJaJ4hjzCJ,PJaJ,hjzCJ PJ\aJ hjzCJ PJ\aJ mH sH   ,>@BDNP, :  t"*d$da$$d1$XDYDa$ $1$a$$`a$$da$dG$H$YD2`  $ & ( , . h j " 0 2 4 : < v x  " $ ( * , . h j z | ~  ȺȺȺȺȺȺֺȯ֯ȺhjzCJ PJaJ o(hjzCJ PJaJ mH sH jhjzCJ PJUaJ hjzCJ PJaJ hjz0JB*CJ PJaJ phjhjzPJU hjzPJE: , d  $.Zj" & FdWDXDYD` dWD` $ .da$0`0 n dd t"*d   H J Z \ ^ d f   > @ F ` b   JLrtv"кккккhjzCJ,PJaJ,hjzhjz0J>*B*aJphjhjzPJUaJhjz0JB*CJ PJaJ ph hjzPJjhjzPJUhjzCJ PJaJ mH sH jhjzCJ PJUaJ hjzCJ PJaJ 9"$.ZjJ*,"&(Bfjlzt!v!z!! "$$$$$$☦tjhjzCJ EHaJ jhjzCJ EHUaJ hjzCJ EHaJ o(hjzCJ H*PJaJ hjzCJ PJaJ mH sH hjzCJ H*PJaJ hjz5CJ KHPJ\hjzCJ OJQJaJ o(hjzCJ PJaJ o(hjz@CJ PJaJ hjzCJ PJaJ hjzCJ OJQJaJ hjzCJ aJ #"tH"BfNfzVpDf dWD`gds dWD`dWDXDYD` dWD`JXnLP`.!!! "n""# dWD` dWD` dG$H$WD`dG$H$WD`gds dWD`gds#F#x####$<$f$$$$&%%%% &T&&&&''8'''( dWD`ddh dWD`$$$$D%F%%%%%T&\&^&&&&&&''H)P)R)))θtk]kL jI hjzCJ UVaJ o(jhjzCJ UaJ o(hjzCJ aJ o(hjz5CJ KHPJ\jhjzCJ EHUaJ !jI hjzCJ EHUVaJ hjzCJ EHaJ jhjzCJ EHUaJ hjzCJ EHaJ o(hjzCJ H*PJaJ hjzCJ PJaJ hjzCJ aJ jhjzCJ EHUaJ !jI hjzCJ EHUVaJ ((H))))))(*b**++2,v,,,-4-j--- ..(.ddh dWD`WD`dX dWD`))))X,Z,^,j,l,p,v,~,,,,,,,,,- - -$-.-2------.··Ьuзззззj\RhjzCJ EHaJ jhjzCJ EHUaJ hjzCJ EHaJ o(jVhjzCJEHUaJ!jI hjzCJEHUVaJhjzCJEHaJjhjzCJEHUaJhjzCJEHaJo(hjzCJ H*PJaJ hjzCJ PJaJ mH sH hjzCJ PJaJ hjzCJ aJ jhjzCJ UaJ o(jhjzCJ EHUaJ o(.... ...../////// 00<0>00 1^2p222 3 3$3<3334.4r4445f5ҫshhssssshjzCJ PJaJ o(hjz5CJ KHPJ\hjzCJ OJQJaJ j hjzCJ EHUaJ !jI hjzCJ EHUVaJ hjzCJ EHaJ hjzCJ H*PJaJ hjzCJ PJaJ hjzCJ aJ jhjzCJ EHUaJ jS hjzCJ EHUaJ !jI hjzCJ EHUVaJ &(.b..(/H////0B000 1^2p2$3<3334.4 $$dWD`$$ & FdG$H$WDXDYD` dG$H$WD` dXWD` dWD`.4r4445h5~556>7T778889::$$dG$H$WD`$$dG$H$WD`gdsdG$H$WD`gdsdG$H$ dG$H$WD` $$dWD` dG$H$WD`f5|5~5>7R7T778888::;;<<<<<"=$=R=X=v==>>4@6@8A>~>>?A:BCEFFFG dG$H$WD`$$ & FdG$H$WDXDYD`$$dG$H$WD`$$dG$H$WD` dG$H$WD`G^GtGGGGHrHHmJmhmmmmڹڤڤڤڱڕڤڹڹڤڤhjzCJ OJQJaJ o(hshjz@CJ PJaJ hjz5CJ KHPJ\hjzCJ aJ hjzCJ OJQJaJ hjzCJ PJaJ hjzCJ PJaJ o(hjzCJ PJaJ hjzCJ PJhjzCJ PJaJ hjzCJ PJo(5L4MdMvMMMMN.N^NNN(O@OdOOOOO$PDPfP~PPPP dG$H$WD` dG$H$WD`dG$H$PQ@QRQxQQQQQ2RfRxRRRRS*SFSfSSSJT`T$$ & FdG$H$WDXDYD`dG$H$ dG$H$WD` dG$H$WD``TvT UV"WWLXXDY`YYYZ(ZLZnZZ4[[[T\n\]b]^$$dG$H$WD` dG$H$WD` dG$H$WD`^^n___4````$aa\b c cBcccddjeteee\f$$dG$H$WDXDYD` dG$H$WD`$$dG$H$WD`\fhVjkHlll>mJmhmmmm(n\nnnDooppp"q$$dG$H$WD`$$ & FdG$H$WDXDYD` dG$H$WD`m(n\nnnDooppp"qpqqqBrrs\ssss<$x@:xhƭJNTVtv|hjzCJ OJPJaJ hjzOJPJaJhjz5CJ aJ hjzCJ,PJ\aJ,!hjzCJ OJPJQJ^JaJ o(hjzCJ aJ hjz5CJ H*PJhjz5CJ PJhjzCJ H*PJaJ Uhjz5CJ KHPJ\hjzCJ PJaJ 4"qpqqqBrrs\sss<$x@:xh$$dG$H$WD`$$dG$H$WD` dG$H$WD` Nnx[VP[Uncertainty factor, UF sS[hQ|pe0:N㉳Q1uRir[DeYcNv Nnx[V }SNk'`De,g@bS+Tv Nnx[V } nvlbc|pe0 Nnx[|pe8^:N100 FOS9hncSeegn0tS'`(0k'`'Y\0N"yrp0Ąy'`0ՋDeegnI{V }~TQ Nnx[|pev'Y\0 10.13 ScSvLvΘiAcceptable Risk of Cancer Y:N>yOlQv^:NlQOcSv~uLvΘiis 8^^\N10-5 SVe00Wp0agNTlQOvcSR N T0 10.14 T25 [S$vSusۏL!hckT _w25%v[RirQs$vvBRϑ0 10.15 keAQDdeQϑAcceptable Daily Intake ADI /fcN~ukeNߘirbn4l-NDdeQgySf[ir( [eP^eNUO]w NoHe^vBRϑ0 10.16 keSDdeQϑTolerable Daily Intake TDI /fcN~ukeDdeQgyir( [eP^eNUO]w NoHe^vBRϑ0 10.17 SBRϑReference Dose RfD sXN(zzl04l0WX0ߘTI{ -NSf[ir(ves^GWcBRϑv0O

f:y 勧NT(Wck8^0TtSSvO(u`Q N NO[NSOeP^ bqS[0 N0NT{N 10NT Ty 20NTO(uvvSO(ue_ 30eGWO(uϑ g/day 40{YuVP[ 50vQN N0NTMe & & MeSRN[?QzSYT & & N0Me-NTbRv[hQċ0O 1. qS[Ƌ+R N,Sb 1 %`'`k'` 2 :Ro'`/P'` 3 Oe'` 4 IQk'` 5 IQS`S^ 6 W Ok'` 7 ͑ YBRϑk'` 8 ukSk'` 9 ba'`k'`/Lv'` 10 kNRRf[ 11 N[hQDe 2. BRϑS^sQ|ċ0O: & & 3. f2ċ0O: & & 4. Θiyr_c: & & mQ0SX[(WvΘiir(ċ0O & & N0Θic6Rceb^ Yf:y(u0O(uel0O(uNI{0 kQ0[hQċ0O~ N,SbNTtS3z['`ċ0O~NT_uir3z['`ċ0O~NSO[hQpenc Y4N^penc0m9O(ug0 NoS^U_I{0hKm~ TSevċ0O~I{ ]N0[hQċ0ONXT~{ T & & AS0[hQċ0ONXT{S & & ASN0Se.s & & ASN0DU_ SbhKmbJT0mSvSe(ϑĉf:y 勧NT(Wck8^0TtSSvO(u`Q N NO[NSOeP^NuqS[0 N0NT{N 10NT TyxxxSOsN 20NTO(uelSmbNhQ 30eGWO(uϑg/day 7.82* 40{YuVP[1.00 50hQf2ϑSED SED=eGWO(uϑ{YuVP[bR(WMe-N~vRk~v8T6esSO͑# l* eGWO(uϑS 0THE SCCS NOTES OF GUIDANCE FOR THE TESTING OF COSMETIC INGREDIENTS AND THEIR SAFETY EVALUATION 10TH REVISION 00 # SO͑N,:N؞vbNSO͑60 kg ~v8T6esN100%0 N0NTMe ,gMe-N@bO(uvSeGW]ReQ 0]O(uSYTSevU_ 0b 0SYT[hQb/gĉ 02015t^Hr 0NTMehh1 NT[EbR+Tϑhh20 h1 NTMeh ^S-Ne TyINCI Ty/e TyO(u vv(W 0]O(uSevU_ 0-Nv^SYl14lWATERnBR0626024lWATERmBR062601,3NNPROPANEDIOL00006X҉FUCUS VESICULOSUS cSirFUCUS VESICULOSUS EXTRACT047283|PARFUMBR070084uARACHIDYL ALCOHOLmBR029925'lYNPHENOXYETHANOL2PBR01294 0SYT[hQb/gĉ 0Q(u2PBRh4 ^S376Apis mellifera HONEYOnBR023417Nhip/(lxDIPALMITOYL HYDROXYPROLINEOnBR02255l,gMeN:N:yO ^[EMe0NTMe^cOhQ萟Se v^ c+TϑQz^cR0 h2 NT[EbR+Tϑh hQ-Ne TyINCI T[EbR+Tϑ% 4lWATER97.09991,3NNPROPANEDIOL1.0000|PARFUM0.6000uARACHIDYL ALCOHOL0. 6000'lYNPHENOXYETHANOL0.5000X҉FUCUS VESICULOSUS cSirFUCUS VESICULOSUS EXTRACT0.1000Apis mellifera HONEY0.1000Nhip/(lxDIPALMITOYL HYDROXYPROLINE0.0001V0Me-NTbRv[hQċ0O 1SSe4l ,gNT@b(uv4l/f~Ǐ_T[Ǐn yP[Nbc pmp̃I{]z_v~S4l e[hQ'`Θi0 2SSe4l01,3-NNTX҉FUCUS VESICULOSUS cSirvmTir0 4l ,gNT@b(uv4l/f~Ǐ_T[Ǐn yP[Nbc pmp̃I{]z_v~S4l e[hQ'`Θi0 1,3-NN %`'`k'`%`'`~Sk'`Ջ>f:y募Se:NNOk'`v:Ro'`bRSm^:N100%e[v g{_:Ro'`100 Se(W,gNT-N^(uΘi(WScSVKNQ0 X҉FUCUS VESICULOSUS cSir VSYTSeċNYXTOCIR ċ0O~g>f:y Sm^ NؚN5%e募Se(WSYT-NvO(u/f[hQv[3] 募SevmRϑ:N0.1000% (W,gNT-N^(uΘi(WScSVKNQ0 3SSe| NT-N@bO(uv|&{TIFRA fNBl0 4SSeu :N1-NASp ^\NvqT0vqT{|ir(v(uRP[~g_:NCnH2n+2O {|ir(wQ gvx~g NwQ g+gzW\O:NsQ.[V Sf[~gv:S+R/fxwv N T0Vdk uTwQ gяf:y募Se:N[Eek'`0%`'`~vk'`Ջ>f:y募Se:N_k'`0v:Ro'`9hncSeO^FUcOvktf[[hQpenc Sm^:N50%e 募Se[ve:Ro'`0 1000募Se(W,gNT-Nv^(uΘi(WScSVQ0 5SSe'lYN 0SYT[hQb/gĉ 02015t^Hr h4SYTQ(u2PBRĉ[ 'lYNvP(uϑ:N1%[7] ,gMevmRϑ:N0.5000% &{TBl0募Se(W,gNT-N^(uΘi(WScSVKNQ0 6SSeApis mellifera  募Seev:Ro'`0f:yvQŔ0^l07x0I0NAVph~g&{T 0SYT[hQb/gĉ 02015t^Hr h2 0SYT-N g[ir(Pϑ 0vPf:y @b gbR(W,gNTSm^ N NO[NSOeP^NuqS[ 20SX[(Wv[hQ'`Θiir(hKmSċ0O~g>f:y NO[NSOeP^NuqS[ 302PBRcb~g&{T gsQBl 40_uirh~g>f:y勧NT_uir&{T 0SYT[hQb/gĉ 02015t^Hr gsQBl 50 g[ir(hKm~g>f:y 勧NT g[ir(+Tϑ&{T 0SYT[hQb/gĉ 02015t^Hr gsQBl; 60NTvtSyr'`03z['`hKm~g>f:y &{TvsQBl 70NTNSňPgevv['`ċ0O~g>f:y &{TvsQBl 80Me-NTbRKN*gSu g[vvN\O(u0 ~ N :N勧NT(Wck8^STt0SvO(uagN N NO[NSOeP^NuqS[0 kQ0[hQċ0ONXT~{ T ċ0ONxxx eg20xxt^xxgxxe 0W@Wxxxxxxxxxxxxxx ]N0[hQċ0ONXT{S xxxxxx AS0Se.s NO 1. V[ߘToTvcw{t;`@\ sQNS^SYT[hQb/gĉ2015t^Hr vlQJT 2015t^,{268S 2. Ralph Gingell, Jeannie B. Kirkpatrick, and David R. Subchronic Toxicity Study of 1,3-Propanediol Administered Orally to Rats. International Journal of Toxicology, 2000,19: 27 32 3. Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics. Final report 2019 available from CIR fSe.s cgqf:y 勧NT(Wck8^0TtSSvO(u`Q N NO[NSOeP^NuqS[0 N0NT{N 10NT Tyxxxb 20NTO(uel,gNTSmbNb0 30eGWO(uϑ g/day 1.54* 40NT{YuVP[ 1.00 50f2BRϑSED =eGWO(uϑ{YuVP[bR(WMe-N~vRk~v8T6esSO͑# l*eGWO(uϑS 0THE SCCS NOTES OF GUIDANCE FOR THE TESTING OF COSMETIC INGREDIENTS AND THEIR SAFETY EVALUATION 10TH REVISION 00 # SO͑N,:N؞vbNSO͑60 kg ~v8T6esN100%0 N0NTMe ,gMe-N@bO(uvbRGW]ReQ 0]O(uSYTSevU_ 0b 0SYT[hQb/gĉ 02015t^Hr NTMehh10 h1 NTMeh ^S-Ne TyINCI Ty/e TyO(u vv(W 0]O(uSevU_ 0-Nv^SYl14lWATERnBR062602ulGLYCERINOnBR024213!CETYL ALCOHOLX zBR035264uARACHIDYL ALCOHOLmBR029925'lYNPHENOXYETHANOL2PBR01294 0SYT[hQb/gĉ 0Q(u2PBRh4 ^S376|PARFUMBR070087Nhip/(lxDIPALMITOYL HYDROXYPROLINEOnBR02255l,gMeN:N:yO ^[EMe0NTMe^cOhQ萟Se v^ cgq+TϑQz^cR0 V0Me-NTbRv[hQċ0O h2 TbRv[hQċ0O ^S-Ne Ty+Tϑ%  0SYT[hQb/gĉ 0BlCgZ:ggċ0O~,gONSeSSO(uϑ% gؚSSO(uϑ% ċ0O~Se.s14l91.699,gNTO(uv4l&{TV[n(u4lhQ e[hQΘi0/2ul5.000CIRċ0O~g>f:y {Yu{|SYTSm^:N78.5%e (WSYT-NvO(u/f[hQv,gMe-NmRϑ(W[hQ(uϑNQ013!1.0001.500(WYHhS:Nxxxvb-N !Sm^:N1.500% ,gNTmRϑ:N1.000% 募Se(W,gNT-N^(uΘi(WScSVKNQ0/4u0. 600u:N1-NASp ^\NvqT0vqT{|ir(v(uRP[~g_:NCnH2n+2O {|ir(wQ gvx~g NwQ g+gzW\O:NsQ.[V Sf[~gv:S+R/fxwv N T0Vdk uTwQ gяf:y募Se:N[Eek'`0%`'`~vk'`Ջ>f:y募Se:N_k'`0 v:Ro'`9hncSeO^FUcOvktf[[hQpenc Sm^:N50.000%e 募Se[ve:Ro'`0 f:yevIQk'`0 zS'`9hncSeO^FUcOvktf[[hQpenc 募See\o(WWVzS'`bgrSOxuS'`0 |~k'`~ǏqS[yr_c 募Sev*g‰[0R g[\O(uvBRϑNOAEL :N 1000 mg/kg bw/day0ukSk'`募SevNSSir1-NASN(W͑ YBRϑk'`/ukTSk'`Ջ-N*g‰Km0RSTukk'`S^ vQNOAEL:N 1000 mg/kg bw/day0SNNSSir1-ASkQ(WukTSk'`Ջ-N_N*g‰Km0RSTukk'`S^ vQNOAEL:N 2000 mg/kg bw/day0tNSf[~gvv 100 募Se(W,gNT-Nv^(uΘi(WScSVQ02-55'lYN0.500&{T 0SYT[hQb/gĉ 0Q(u2PBRh4 ĉ[n 0SYT[hQb/gĉ 02015t^Hr Bl066|0.200vQO(u&{TVEe(ueOSOIFRA [lĉBl0/7Nhip/(lx0.0015募SeO(uSm^NON]ybQ{Yu{|SYT-NgؚSSf(uϑ S[hQO(u0/ N0SX[(WvΘiir(v[hQċ0O ,gNT cgq 0SYT[hQċ0Ob/g[R 0vBl WNS_MRyf[w4ls^ [S1uSYTSe&^eQ0uNǏ z-NNub&^eQvΘiir(ۏLċ0O ~ghf ,gNTvuN&{TV[vsQl_lĉ [uNǏ zTNTSňPgeۏL%N-Nh2 SYT-N g[ir(Pf:yvQŔ0^l07x0I0NAVph~g&{T 0SYT[hQb/gĉ 02015t^Hr h2 0SYT-N g[ir(Pϑ 0vPf:y @b gbR(W,gNTSm^ N NO[NSOeP^NuqS[ 20SX[(Wv[hQ'`Θiir(hKmSċ0O~g>f:y NO[NSOeP^NuqS[ 30_uirh~g>f:y勧NT_uir&{T 0SYT[hQb/gĉ 02015t^Hr gsQBl 40 g[ir(hKm~g>f:y 勧NT g[ir(+Tϑ&{T 0SYT[hQb/gĉ 02015t^Hr gsQBl; 50Me-NTbRKN*gSu g[vvN\O(u0 ~ N :N勧NT(Wck8^STt0SvO(uagN N NO[NSOeP^NuqS[0 kQ0[hQċ0ONXTv~{ T ċ0ONxxx eg20xxt^xxgxxe 0W@Wxxxxxxxxxxxxxxxx ċ0ONxxx eg20xxt^xxgxxe 0W@Wxxxxxxxxxxxxxxxx ]N0[hQċ0ONXT{S & & AS0Se.s NO 1. V[ߘToTvcw{t;`@\ sQNS^SYT[hQb/gĉ2015t^Hr vlQJT 2015t^,{268S 2. Ralph Gingell, Jeannie B. Kirkpatrick, and David R. Subchronic Toxicity Study of 1,3-Propanediol Administered Orally to Rats. International Journal of Toxicology, 2000,19: 27 32 3. Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics. Final report 2019 available from CIR ASN0DU_ 10SeO^FUcOv1,3-NN0uktf[bJT 20O(u!vYHhS:NxxxvbDe 30NT-NNu0ZhKmbJT 40|vIFRAfN lDU_@bcOvDeN[:yObJT ؏S9hncNT[E`QcOSeO^FUcOv&{TBlvfeN 9hncSeO^FUcOvPgec{QvΘiir(Sm^ SeO^FUcOvvQN|feNb&{TGB/T 22731-2017 e(u|hQXfI{vQNfeN0            PAGE \* MERGEFORMAT 14   PAGE \* MERGEFORMAT0   PAGE \* MERGEFORMAT60     PAGE \* MERGEFORMAT64   ƭڮJLVXZ\vxz|$ & F t dhG$H$a$  & F tdh$a$$da$@d^@ & FdG$H$$$dG$H$WD` dG$H$WD`>@d ",0246@BJLNRbdfhvx~湳wgwgwgwghjzCJ OJPJaJ mH sH hjzCJ OJPJaJ o(hjzCJ OJPJaJ hjzCJ PJaJ !hjzCJ,OJPJQJ^JaJ,o(hjzCJ aJ hjzaJhjzCJOJPJaJhjzCJ OJPJaJ mH sH !hjz>*CJ OJPJaJ mH sH hjzCJ OJPJaJ hjz>*CJ OJPJaJ (@026@BRj~̱ & F tt"*dG$H$WD` $dWD`a$$da$$da$$ & F tdhG$H$a$ & F tdhG$H$ & F tdhG$H$WD`ıƱȱ̱ "$&(,6xzҳԳ68JLNPƺhjzCJ PJaJo(hjzCJ PJaJhjzCJ PJaJ hjzCJ OJQJ\aJ hjzCJOJPJaJ!hjz5CJ OJPJaJ mH sH hjzCJ OJPJaJ mH sH hjzCJ OJPJaJ o(hjzCJ OJPJaJ 8(*,6vг޳2FĴ d1$G$H$d1$XDYD & F t0dhG$H$WD`0 & F tt"*dG$H$WD`Ĵ "(>DVҶض $.ķַǹ߹߹߹韹髒ypfZhjzCJ OJPJaJ hjzOJPJaJhjz5CJ aJ hjzCJ,PJ\aJ,hjzCJ KHOJQJaJ hjzCJ KH^JaJ o(hjzCJ OJQJaJ hjzCJ OJPJQJaJ hjzCJ OJPJQJaJhjzCJ PJaJhjzCJ PJaJmH sH hjzCJ PJaJhjzCJ OJQJ\aJ hjzCJPJaJ!Ĵ 0DVlȵֵ "(>DVd1$XDYDd1$XDYD d1$G$H$ d1$G$H$VҶض $.· & F tdhG$H$$G$H$a$$a$d1$G$H$XDYDd1$XDYDd1$XDYDd1$G$H$XDYD·ķ6|68:<>BLN $dWD`a$$da$$da$ & F tdhG$H$WDX` & F tdhG$H$WD`$ & F tdhG$H$a$ & F tdhG$H$ַ4Jzĸ$&26>@BLNVX^jlp~ڹܹ,.2HJN^`dpпhjzCJ OJPJaJ mH sH hjzCJ OJPJaJ o(hjzCJ OJPJaJ hjzCJ PJaJ !hjzCJ,OJPJQJ^JaJ,o(hjz hjzaJhjzCJOJPJaJhjzCJ OJPJaJ hjz>*CJ OJPJaJ 7N^r4Pfxz|~ d1$G$H$d1$XDYD & F tdhG$H$ & F tdhG$H$^ & F tH0dhG$H$WD^H`0 & F tt"*dG$H$WD`prvx|~ƻȻ(.PVrn½޽wwmm_wm_wm_whjzCJ PJaJ mH sH hjzCJ PJaJ hjzCJ OJPJQJaJhjzCJ PJaJ o(hjzCJ PJaJ hjz5CJ OJPJQJaJ hjzCJ PJaJhjzCJ OJQJ\aJ hjzOJPJaJhjzCJOJPJaJhjzCJ OJPJaJ hjzCJ OJPJaJ mH sH hjzCJ OJPJaJ o(%Ļ(.PVrȼؼ*D d1$G$H$gds d1$G$H$ & Fd1$XDYD d1$G$H$d1$XDYDDXn½޽"6Ⱦ޾"L d1$G$H$d1$XDYDd1$XDYDd1$XDYDgds d1$G$H$gds޽"6Ⱦ޾"LNTVX|b~ <HxǶuuuuuuuuhjz>*CJ OJPJaJ hjzCJ OJPJaJ hjzOJPJaJ hjzaJhjzCJ,PJaJ,hjzhjzCJ PJaJ !hjzCJ OJPJQJ^JaJ o( hjzaJhjzCJ PJaJ hjzCJ OJPJQJaJ hjzCJ OJQJ\aJ hjzCJ OJPJQJaJ)LVXZ\~>z|| & F tdhG$H$WDX` & F tdhG$H$WD`$ & F tdhG$H$a$ & F tdhG$H$$0xxG$H$`0a$$xxa$ $pxx`pa$ 0xx`0$da$ .Bd( dWD`d & F tt"*dG$H$WD` $` dWD`` a$$da$$da$dhG$H$$ & F tdhG$H$a$ &(,:<@\^d~"( ,˻˻˻˻˻˻˻˻˻˻˻}}}hjzCJ PJaJo(hjzCJ PJaJhjzCJ PJ\aJ o(hjzCJ PJ\aJ !hjz5CJ OJPJaJ mH sH hjzCJ OJPJaJ mH sH hjzCJ OJPJaJ o(hjzCJ OJPJaJ hjzCJ PJaJ !hjzCJ,OJPJQJ^JaJ,o(0(0H$d$1$IfYDa$d1$XDYD dWD` dG$H$WD`,.24JL\bd6:Xb<@BFntǼljljǼ||o||hjzCJ H*PJaJo(hjz5CJ PJ\aJhjz5CJPJ\aJo( hjzCJ\hjzCJPJmH o(sH hjzCJPJo(hjzCJPJhjz5CJPJ\hjz5CJPJ\aJhjzCJ PJ\aJ hjzCJ PJaJo(hjzCJ PJaJhjzCJ H*PJaJ+ cTTTTTT$$1$IfYDa$kd$$IfT4ֈ+ m! E44 laT".6?0000$$1$IfYDa$kd$$IfTֈ+ m! E 44 lapT6BDF/kd$$IfT4ֈ+ m! E 44 lapT$$1$IfYDa$FHVnp|~$$1$IfYDa$$h$1$IfYD`ha$~>+$$1$IfYDa$$h$1$IfYD`ha$kdY$$IfT4ֈ+ m! E 44 lapT/kd$$IfT4ֈ+ m! E 44 lapT$$1$IfYDa$(*$$1$IfYDa$*,08\d?0000$$1$IfYDa$kd$$IfTֈ+ m! E 44 lapTdprtx0kdJ$$IfTUֈ+ m! E 44 lapT$$1$IfYDa$0kd$$IfTֈ+ m! E 44 lapT$$1$IfYDa$&24$$1$IfYDa$46:L?0000$$1$IfYDa$kd$$IfTֈ+ m! E 44 lapT0'0d`0kd$$IfTֈ+ m! E 44 lapT$$1$IfYDa$ 46:FV^kdV$$IfToF "^  G 0    44 laytsT$$1$IfYDa$1$VXf~teee$$1$IfYDa$kd$$IfTF "^  G 0    44 laytsTYJJJ$$1$IfYDa$kd$$IfTF "^  G 0    44 lapytsTYJJJ$$1$IfYDa$kdP$$IfTF "^  G 0    44 lapytsT&YJJJ$$1$IfYDa$kd$$IfTF "^  G 0    44 lapytsT&(\YJJJ$$1$IfYDa$kd$$IfTF "^  G 0    44 lapytsTYJJJ$$1$IfYDa$kd$$IfTF "^  G 0    44 lapytsT*8YJJJ$$1$IfYDa$kd $$IfTF "^  G 0    44 lapytsT8:XrYN@@2 dG$H$WD` dG$H$WD` dWD`kdL!$$IfTF "^  G 0    44 lapytsTrPFhJ06$d$1$IfYDa$gdjzl d1$XDYD dG$H$WD` dG$H$WD`nt:DFh8*,@B"4<TlnphjzPJaJhjzCJ PJaJo(hjzCJ PJ\aJ hjzhjzCJhjzhjzCJPJhjzhjz5CJPJ\hjz5CJPJ\aJ!hjzCJ OJPJQJ^JaJo(hjzCJ H*PJaJhjzCJ PJaJhjz5CJ PJ\aJ-68<@DbDDD$d$1$IfYDa$gdjzl kd"$$IfT4F $' 30    44 lapytjzTDFV^cEE$d$1$IfYDa$gdjzl kd"$$IfT7F $' 30    44 lapytjzT^!kd#$$IfT F $' 30    44 lapytjzT$d$1$IfYDa$gdjzl $$d$1$IfWDYD`a$gdjzl 'kdC$$$IfTF $' 30    44 lapytjzT$d$1$IfYDa$gdjzl $d$1$IfYDa$gdjzl  'kd$$$IfTF $' 30    44 lapytjzT$d$1$IfYDa$gdjzl $d$1$IfYDa$gdjzl ($$d$1$IfWDYD`a$gdjzl $d$1$IfYDa$gdjzl cEEE$d$1$IfYDa$gdjzl kd%$$IfT F $' 30    44 lapytjzTcEEE$d$1$IfYDa$gdjzl kdk&$$IfTCF $' 30    44 lapytjzTcEEE$d$1$IfYDa$gdjzl kd#'$$IfTF $' 30    44 lapytjzT"4(cUUUUUUUU dG$H$WD`kd'$$IfTF $' 30    44 lapytjzT (rP<TlTrPd dG$H$WD`nxz|~ L & F tdhG$H$WD`$ & F tdhG$H$a$ & F tdhG$H$ 0xG$H$`0 $0xG$H$`0a$$xa$x$da$ dG$H$WD`pv~ 2J` RXZdrt֕rbrbrhjzCJ OJPJaJ mH sH hjzCJ OJPJaJ o(hjzCJ OJPJaJ hjzCJ PJaJ !hjzCJ,OJPJQJ^JaJ,o(hjzCJ OJPJaJ o(hjz>*CJ OJPJaJ hjzCJ OJPJaJ hjzOJPJaJhjzhjzCJ,PJaJ,hjzCJ PJaJ !hjzCJ OJPJQJ^JaJ o(&R<Tp $dWD`a$ & F tt"*dG$H$WD`$da$$ & F tdhG$H$a$ & F tdhG$H$WDX`46<LNPThjlp~4B"`ʿ hjzCJ\hjzCJPJaJhjz5CJPJ\aJhjz5CJPJ\aJhjzCJ H*PJaJhjzCJ PJaJhjzCJ PJ\aJ hjz5CJOJPJaJhjzCJ OJPJaJ o(hjzCJ OJPJaJ hjzCJ OJPJaJ mH sH 2.V4B $$1$G$H$IfYDa$1$ dG$H$WD` "&*6<HJcQQQQQQ$$1$G$H$IfYDa$kd($$IfT4ֈ<?!m]44 laTJLPVhp?----$$1$G$H$IfYDa$kdH)$$IfTDֈ<?!m] 44 lapTp|~-kdo*$$IfTDֈ<?!m] 44 lapT$$1$G$H$IfYDa$-kd+$$IfTֈ<?!m] 44 lapT$$1$G$H$IfYDa$$$1$G$H$IfYDa$ 4<?----$$1$G$H$IfYDa$kd,$$IfTֈ<?!m] 44 lapT<Hz|-kd.$$IfTֈ<?!m] 44 lapT$$1$G$H$IfYDa$-kd_/$$IfTQֈ<?!m] 44 lapT$$1$G$H$IfYDa$ $$1$G$H$IfYDa$bd?6( ?XDdYD2`0d`0kd0$$IfT]ֈ<?!m] 44 lapT`bd.2FL@j:"4      n x z     úúúúٔ|qfhjzCJ PJaJ o(hjzCJ PJaJo(hjzCJ PJ\aJ o(hjzhjzCJPJhjzhjz5CJPJhjzCJ PJaJ hjzaJhjzhjzCJo(hjzhjzCJhjzhjzCJ\hjzhjz5CJ\hjz5CJPJ\aJhjzCJ PJ\aJ hjzCJhjz5CJ\(d",.26DFHJL|Ff6Ff03$$Ifa$gdjzl 1$ dhG$H$WD` *,.:<Ff >$IfWD`gdjzl $$Ifa$gdjzl Ffo:$$Ifa$gdjzl ,:N|$$Ifa$gdjzl $$If`a$gdjzl $$Ifa$gdjzl $$Ifa$gdjzl 4<>BLXFfIE$$If`a$gdjzl $$Ifa$gdjzl FfA$$Ifa$gdjzl $$If`a$gdjzl  "&8DFHJNL dG$H$WD`$0`0a$FfLFfH$$If`a$gdjzl $$Ifa$gdjzl L@jx$d$G$H$Ifa$gdjzl 1$ dG$H$WD`bFFF$d$G$H$Ifa$gdjzl kdN$$IfT4F dz"x X0    44 lapytjzT cGG'$d$G$H$If`a$gdjzl $d$G$H$Ifa$gdjzl kdO$$IfT:F dz"x X0    44 lapytjzT >@HLG++$d$G$H$Ifa$gdjzl kdNP$$IfTYF dz"x X0    44 lapytjzT$d$G$H$Ifa$gdjzl LPRZ^bGkdQ$$IfT:F dz"x X0    44 lapytjzT$d$G$H$Ifa$gdjzl bdn|NcGG(d$G$H$IfWD`gdjzl $d$G$H$Ifa$gdjzl kdQ$$IfT:F dz"x X0    44 lapytjzTN D(($d$G$H$Ifa$gdjzl kdvR$$IfT' F dz"x X0    44 lapytjzTd$G$H$IfWD`gdjzl 048Gkd.S$$IfT:F dz"x X0    44 lapytjzT$d$G$H$Ifa$gdjzl 8:"4&cUUUUUUUU dG$H$WD`kdS$$IfT:F dz"x X0    44 lapytjzT &p, \      " : X        n z      dG$H$WD` dG$H$WD`  "$&(*,.068:<@BDFH$a$0`0$h`ha$h`hh&dP`h  04<>@PRdfnptvɵڅuhh\hhjzB*mHphsHjhjzB*UphhjzB* CJOJQJ^JphhshjzB*CJaJph"h02qB*CJaJmHnHphuhshjzB*CJaJph&jhshjzB*CJUaJph hshjzB*CJaJo(ph hshjzB*CJaJo(phhjzB*phhjzjhjzU$HJLNPTVXZ\^`bdhjln$h`ha$$a$gds $ 9h`ha$h`h$h`ha$h`h0`002tvxz$a$gds "&(,.0248:dfjlprtxzԷԟ㳃hjzCJ PJaJ o( jhshjzCJUaJ*&h02qh02qCJaJmHnHsHu*hjz#h02qh02qCJaJmHnHsHuhshjzCJaJjhshjzCJUaJhshjzCJaJo( hshjzB*CJaJo(ph=0P1?2P. A!"#$%S Dp:P1?2P. A!"#$%S Dp01?2P. A!"#$%S 01?2P. A!"#$%S 31G2P0A .!"#$%S 01?2P. A!"#$%S Dd % /Xix  :A?(8? [a 73"2e|[|=QL|@D`!e|[|=QL|@kpxcdd``e 2 ĜL0##0KQ* WORcgbR qP7$# aPD.#lKA,a ˉL !*'] ZZOKYGYLm`60>4'P|Ƶ ~b%ľȳ p{y@fh1/f!|Fo. nP;0Sa*Y@:\9&:0Uİ n]a6'sِL@|[W.h,sS  0y{@^hcdbR ,.Ie rPCXHo sTDd @S?2x  :A?(8? [a 83"2& l7&kPd`!\& l7&kP< WpXJ*xcdd``cd``baV d,FYzP1n:&&.! KA?H1 ] UXRYP7&meabM-VK-WMcXɥѣp P.P16 YP 1?cd:0ey_ 2gb9|f +%% $ FK fAgm] P``Ĥ\Y\ˠ Dx**`wchDd   DA?(8?Object 133"2k*ݦ% 3c;n2`!fk*ݦ% 3c;: :4xcdd``$d@9`,&FF(`T)GRcgbR nyfĒʂT @_L ĺE612X@:n;3Q9B&br @c112BYL%bpuFÆ02yPCX(3C}1= L@xۃ%u">$0MbaM\6b;6F&&\j @ ]` W>I0crDd wCz  <A?(8? [a 103"2`k`j0D `!x`k`j0DZ  Fxcdd``e 2 ĜL0##0KQ* Wô A?dxfĒʂT$/&`b@f0mb b Y wfRQ9B&br<7_$|\=ʞʤy@der)ļ3 ps1fL4 X Q`re8DAweם96dm)5 = O121)W2xa`k)M=VhZDd z  <A?(8? [a 113"2~0gfXUgh `!`~0gfXUg4 :.xcdd``$d@9`,&FF(`T) A?d @=P5< %! 8 :@u!f0mb| b Y wf:r؅,L ! ~ Ay oH0450zI;1c#LsXavtK1Jls R` artD${~j}&\X] `P8121)W2a"n|`b @U$$If!vh#v #v#v#v#vE#v:V 4,5 5555E5/ /  / aT%$$If!vh#v #v#v#v  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~"#Root Entry# F-Data TWordDocument"FObjectPool% p}--_1234567890Fp}-p}-Ole CompObjiObjInfo  #&()*+,-/0123456789:;<=>?@ABCDEG FMicrosoft ʽ 3.0 İ DS Equation Equation.39qu$*[ SED=DA a SSAFBW10 -3Equation Native _1234567891 Fp}-p}-Ole CompObj i !Fʽ༭ 3.0 İ DS EquationEquation.KSEE39q5>Wd,Y SED=ACDA p !Fʽ༭ 3.0 İ DS EquationEquation.KSEE39qObjInfo Equation Native  Z_1234567892Fp}-p}-Ole  CompObjiObjInfoEquation Native r_1234567893Fp}-p}-`V{m+a MoS=NOAEL(BMD)SED FMicrosoft ʽ 3.0 İ DS Equation Equation.39q­hT)\ HT 25 =Ole CompObjiObjInfoEquation Native T 25  )BWN BWRir ()  0.25 FMicrosoft ʽ 3.0 İ DS Equation Equation.39qO & LCR=SE_1234567894Fp}-p}-Ole CompObjiObjInfoEquation Native k_1234567895Fp}-p}-Ole !CompObj "iD4HT 25 FMicrosoft ʽ 3.0 İ DS Equation Equation.39qB"\ AEL=NESILSAF Oh+'0xObjInfo!$Equation Native %^1Table'8ASummaryInformation($'      !$%&()*+,-./0123456789:;<=>?@ABCDEFG#vE#v:V  ,5 5555E5/ /  /  / / /  apT\$$If!vh#v #v#v#v#vE#v:V 4 ++,5 5555E5/ /  / / /  / / / / apT\$$If!vh#v #v#v#v#vE#v:V 4 ++,5 5555E5/ /  / / /  / / / / apTN$$If!vh#v #v#v#v#vE#v:V 4 ++,5 5555E5/ /  / / /  / / / apTA$$If!vh#v #v#v#v#vE#v:V  ,5 5555E5/ /  / / /  / / / apTA$$If!vh#v #v#v#v#vE#v:V U ,5 5555E5/ /  / / /  / / / apTA$$If!vh#v #v#v#v#vE#v:V  ,5 5555E5/ /  / / /  / / / apTA$$If!vh#v #v#v#v#vE#v:V  ,5 5555E5/ /  / / /  / / / apTA$$If!vh#v #v#v#v#vE#v:V  ,5 5555E5/ /  / / /  / / / apT$$If!vh#v^ #v #vG :V o0,5^ 5 5G aytsT$$If!vh#v^ #v #vG :V 0,5^ 5 5G aytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v^ #v #vG :V  0,5^ 5 5G apytsT$$If!vh#v' #v3#v:V 40,5' 535apytjzT$$If!vh#v' #v3#v:V 70,5' 535apytjzT$$If!vh#v' #v3#v:V  0,5' 535apytjzT$$If!vh#v' #v3#v:V 0,5' 535apytjzT$$If!vh#v' #v3#v:V 0,5' 535apytjzT$$If!vh#v' #v3#v:V  0,5' 535apytjzT$$If!vh#v' #v3#v:V C0,5' 535apytjzT$$If!vh#v' #v3#v:V 0,5' 535apytjzT$$If!vh#v' #v3#v:V 0,5' 535apytjzT$$If!vh#v!#v#v#v#vm#v]:V 4,5!5555m5]/ /  / aT%$$If!vh#v!#v#v#v#vm#v]:V D ,5!5555m5]/ /  /  / / /  apT%$$If!vh#v!#v#v#v#vm#v]:V D ,5!5555m5]/ /  /  / / /  apTA$$If!vh#v!#v#v#v#vm#v]:V  ,5!5555m5]/ /  / / /  / / / apTA$$If!vh#v!#v#v#v#vm#v]:V  ,5!5555m5]/ /  / / /  / / / apTA$$If!vh#v!#v#v#v#vm#v]:V  ,5!5555m5]/ /  / / /  / / / apTA$$If!vh#v!#v#v#v#vm#v]:V Q ,5!5555m5]/ /  / / /  / / / apTA$$If!vh#v!#v#v#v#vm#v]:V ] ,5!5555m5]/ /  / / /  / / / apTI$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 40, 55p557555p5O5 apZytjzTWkd1$$IfT4  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkd5$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkd'9$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkd<$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkdc@$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkdD$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkdG$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzTF$$If!v h#v#vp#v#v7#v#v#vp#vO#v :V 0, 55p557555p5O5 apZytjzTTkd=K$$IfT  Lb#5i:p7pO0$$$$44 lapZytjzT$$If!vh#vx #vX#v:V 40,5x 5X5apytjzT$$If!vh#vx #vX#v:V :0,5x 5X5apytjzT$$If!vh#vx #vX#v:V Y0,5x 5X5apytjzT$$If!vh#vx #vX#v:V :0,5x 5X5apytjzT$$If!vh#vx #vX#v:V :0,5x 5X5apytjzT$$If!vh#vx #vX#v:V ' 0,5x 5X5apytjzT$$If!vh#vx #vX#v:V :0,5x 5X5apytjzT$$If!vh#vx #vX#v:V :0,5x 5X5apytjzT  ( 4 @ LX`hpַʽ Xtzj.User Normal.dotmpc3Microsoft Office Word@F#@)--@X-@X-@Y ՜.+,D՜.+, `h|DocumentSummaryInformation8.CompObjFn  Xtzj.Com5@i ([c _PID_HLINKSKSOProductBuildVerAdT45 _Toc6757572942 _Toc675757284, _Toc675757274& _Toc675757264# _Toc675757254 _Toc675757244 _Toc675757234 _Toc675757224 _Toc675757214 _Toc675757207  _Toc675757197 _Toc675757187 _Toc675757177 _Toc675757162052-10.8.2.7119  FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q"s |00<66666668 0@P`p6(88 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@PJ _HmH nHsH tHJ`J cke $1$a$ CJKH_HaJmH nHsH tH`@` h 1!d2XD22YD2$$@&CJOJPJQJaJ,KH,\<@< h 2 $$@&5KHaJ \$A`$ ؞k=W[SONi@N nfh*B*ph)! uxfo2f h1-1d2WDXDdYD2`$CJOJPJQJ_HmH nHsH tH.B. yblFhe,gCJaJN@RN 0u w'a$$G$&dP 9r CJaJfOf pTOC h2da$$1$@& !B* ph6_CJOJ QJ ^JaJKH$@$ pvU_ 1PoP cke1-1d,WD`CJ_HmH nHsH tH< @< 0ua$$G$ 9r CJaJ`O` hh'2XD22YD2a$$1$WD`CJOJPJQJ^JKH\O\ h-\".B-?7}>FTlon77Ԝx?|+NST2 XiEꭶ?j]m^_^+P[wD+PW-W_YW ͶW5 R ~,VAFXuVKsKTCV]rŦZ-t  ;b6#42% qv8›q. B˟TDFLڐAB&~ ^] ُ=q==~NV;(VG:=ՃxiJ!x?>~?< }a\G5TLx?y;~nьHbwc:EGP~Ds |w<4rg!Rt|+c m߆6Il!Q] sZ;aQITjYV`<$6D='Ienb~k3MHýS^P\wr^+j~k~vt~t«(:zQk_۶sWb/?ѹS)uzݜnrʵ+Am~޽: 5ˁWrbJAүsUTjzf5η1T>汀*^PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!.theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] #%@b,j#%@b!;.?!]b,j?{  "&(********,,0003 "$).f5Lmַp޽,p` z:<>?CEFILR: "#((..4:GLP`T^\f"qĴV·NDL(6F~*d4V&8r6D^( Jp<dL LbN8& Hz;=@ABDGHJKMNOPQS(@A_gj;F`cdf$.2Pa{~%:TWX[`su.AC?RT,j XXXXXX%ĕXXX%ĕXX%ĕX%ĕXX%ĕĕ::::::%;=CY\e{~!!!!@ @  (    |((>MSIPCM240d4fca9d8b6a3f5045af16{"HashCode":-1406602145,"Height":841.0,"Width":595.0,"Placement":"Footer","Index":"Primary","Section":1,"Top":0.0,"Left":0.0}C"?   T(( e,gFh 5S"?    T(( e,gFh 6S"?    T(( e,gFh 7S"?    T(( e,gFh 8S"?  0(  B S  ?",3X@ p>.@j@ @ pl@ p@ p! _Toc67575716 _Toc67575717 OLE_LINK6 OLE_LINK5 _Toc67575718 _Toc67575719 OLE_LINK2 _Toc67575720 _Toc67575721 _Toc67575722 _Toc67575723 _Toc67575724 _Toc67575725 _Toc67575726 _Toc67575727 _Hlk53471796 _Toc67575728 _Toc16405 _Toc24905_Toc2528 _Toc18549 _Toc362852034_Toc3290 RANGE!A1:D107_Toc936 _Toc362852038 _Toc17913 _Toc29387 _Toc401479024_Toc6455 _Toc18105_Toc9616 _Toc675757293 %&-.29=3?A|CMDcEHPPPFSFSS UUFUQUV'X-j     < /&-.29=?ACSDiEHPPeQISS UUFUPU^UV*X-j /2 %&;&22@@EEE0FJFFFFFZ@B;EHJN\JvuM'OPTUTM2V%FVfVI*[O@[ ]$}]u^J_R`1%a(dg>g i^=mn02qurFPsovjz@{r|>~bl3+DYw IVW5<GF^t)byFzd}Ci)-e|c:NTQsb#9F[ (,03-ro8XFN^ W(rxB5+!+e' z?d:r=MC\6Zv71 vGKb[h`">DMuY J&5 L !| ~ 8>p.z5 U\%P)ZF*V3-367:97;[?U? ?jcC}Fe]H H2J5|KLUM0O/P$P!QBTnW:KX2Y-wY Y[\Zh$Zo\hg\8{w_h_/ `J`OaD$bFcXg(g1y$jg7kxokkRmn.H0oYo@oZo%:oqDp[s*tQuawbwLwLx-iy{6{#I|}X}}x}f8~~~t/]wDzd!b@_QyRםgj}2@]׹`'2x&u.ֶׅt>!ڡdwsa8f lջS]ѭ ZK~ Q(P(x]